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Skin DNA methylation profile in atopic dermatitis patients: A case–control study
Author(s) -
Olisova Olga Yu.,
Kochergin Nikolay G.,
Kayumova Lyailya N.,
Zavarykina Tatiana M.,
Dmitriev Alexey A.,
Asanov Aliy Yu.
Publication year - 2020
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.14064
Subject(s) - dna methylation , atopic dermatitis , epigenetics , methylation , immunology , immune system , biology , genetic predisposition , etiology , epidermis (zoology) , atopy , genetics , medicine , gene , allergy , gene expression , anatomy
Atopic dermatitis (AD) is a worldwide disease with a complex aetiology. Both genetic and environmental factors cause a predisposition to AD. DNA methylation may be an additional predisposing factor. The goal of our study was to investigate genome‐wide methylation profiles of skin from patients with AD and healthy persons. This case–control study included 12 AD patients and 6 healthy volunteers. DNA methylation levels in skin samples were analysed using the Illumina Infinium HumanMethylation450 BeadChip. We found that the methylation profile of skin from patients with AD was significantly different from that of healthy controls. Differential DNA methylation was observed for genes involved in a number of AD‐related processes including regulation of the immune response, activation of lymphocytes, cell proliferation, apoptosis and differentiation of the epidermis. Our study indicates the involvement of epigenetic regulation in the development of atopic dermatitis.