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Caveolin‐1 as a possible target in the treatment for acne
Author(s) -
Kruglikov Ilja L.,
Scherer Philipp E.
Publication year - 2020
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.14063
Subject(s) - acne , regulator , caveolin 1 , propionibacterium acnes , biology , innate immune system , normalization (sociology) , transforming growth factor , medicine , cancer research , microbiology and biotechnology , immunology , immune system , gene , genetics , sociology , anthropology
Expression of caveolin‐1 (Cav‐1) is an important pathophysiological factor in acne. Cav‐1 strongly interacts with such well‐recognized etiopathogenic factors such as hyperseborrhea, follicular hyperkeratinization and pathogenicity of Cutibacterium acnes . Cav‐1 is a strong negative regulator of transforming growth factor beta (TGF‐β) expression. It acts as a critical determinant of autophagy, which is significantly induced in acne lesions through C. acnes and by absorption of fatty acids. Cav‐1 also demonstrates different correlations with the development of innate immunity. We propose that normalization of Cav‐1 expression can serve as a target in anti‐acne therapy.