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P63‐related disorders: Dermatological characteristics in 22 patients
Author(s) -
Maillard Alexia,
Alby Caroline,
Gabison Eric,
Doan Serge,
Caux Frédéric,
Bodemer Christine,
HadjRabia Smail
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.14045
Subject(s) - erythroderma , dermatological diseases , dermatology , medicine
In P63‐related ectodermal dysplasias (ED), the clinical characteristics focus on extra‐cutaneous manifestations. The dermatological phenotype remains incompletely characterized. We report the dermatological features of 22 patients carrying a TP63 mutation. Erosions, erythroderma and pigmentary anomalies are characteristics of P63‐related ED. Our data suggest that patients might be classified into two major P63‐related disorders: AEC and EEC. RHS and ADULT represent mild AEC and EEC forms, respectively.