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Impairment of Th cell response in Card9 knockout mice with cutaneous mucormycosis caused by Rhizopus arrhizus
Author(s) -
Sun Lingyue,
Wan Zhe,
Li Ruoyu,
Yu Jin
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.14020
Subject(s) - rhizopus arrhizus , mucormycosis , knockout mouse , cytokine , immunology , biology , receptor , medicine , pathology , biochemistry , enzyme , lipase
Card9 is a signalling adaptor protein in the downstream of many innate pattern recognition receptors (PRRs) and exerts a significant role in antifungal immunity. To date, Card9 deficiency has been reported to be related to increased susceptibility to many fungal infections. In this study, we established mucormycosis murine model of Rhizopus arrhizus ( R. arrhizus ) using wild‐type (WT) mice and Card9 knockout ( Card9 −/− ) mice to investigate the antifungal effect of Card9 against R. arrhizus infection. Card9 −/− mice were more susceptible to R. arrhizus infection than WT mice, which could be related to the impaired NF‐κB pathway activation, local cytokine production and Th cell responses in Card9 −/− mice.