Premium
Interaction of peripheral nerves and mast cells, eosinophils, and basophils in the development of pruritus
Author(s) -
Nakashima Chisa,
Ishida Yoshihiro,
Kitoh Akihiko,
Otsuka Atsushi,
Kabashima Kenji
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.14014
Subject(s) - immunology , immune system , medicine , mast cell , histamine , inflammation , atopic dermatitis , interleukin 33 , immunoglobulin e , basophil , cytokine , interleukin , antibody , pharmacology
Mast cells, eosinophils and basophils are central effector immune cells in allergic skin inflammation including atopic dermatitis (AD). Recent studies revealed that the bidirectional interaction between these three immune cell types (mast cells, eosinophils and basophils) and the nervous system is involved in the pathogenesis of neurogenic inflammation, pain and pruritus. Emerging evidence shows that these cells are the main source of pruritogens such as histamine, neuropeptides and cytokines, which are potential new therapeutic targets for drug development in chronic pruritus. For instance, many Th2 cytokines including interleukin (IL)‐4, 13 and 31 have been recognized as some of the most promising targets for the treatment of chronic pruritus in AD. In this review, we highlight the link between these three immune cell subsets and peripheral nerves, with emphasis on the development of chronic pruritus such as AD. We present cytokines and receptors of these three immune cells and peripheral nerves, and discuss the therapeutic potential of targeting these neuro‐immunological processes.