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Injury modifies the fate of hair follicle dermal stem cell progeny in a hair cycle‐dependent manner
Author(s) -
Abbasi Sepideh,
Biernaskie Jeff
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13924
Subject(s) - hair follicle , hair cycle , stem cell , hair growth , microbiology and biotechnology , biology , andrology , medicine , physiology
The dermal papilla ( DP ) is one of two principal mesenchymal compartments of the hair follicle ( HF ). We previously reported that a population of HF dermal stem cells (hf DSC s) function to regenerate the dermal sheath ( DS ), but intriguingly also contribute new cells to the adult DP at the onset of anagen hair growth to maintain normal cycling of HF s and support the production of large hair fibres. Here, we asked whether injury altered the behaviour of hf DSC s and their progeny in order to support wound‐induced hair growth ( WIHG ) and if the response was modulated by hair cycle stage. α SMAC re ER T 2 : ROSA YFP mice received tamoxifen to label the DS , including hf DSC s. Full‐thickness excisions were made on the dorsal skin during various stages of the hair cycle. The skin was harvested at the subsequent anagen. Interestingly, there was an increase in the magnitude of recruitment of hf DSC progeny into the DP after injury compared to follicles entering natural second anagen. This bias towards a DP fate only occurred when a wound was induced during certain stages of the HC . In summary, injury modifies the fate of hf DSC s progeny, biasing them towards recruitment into the DP , with the hair cycle stage also influencing this response.