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Exosomes in chronic inflammatory skin diseases and skin tumors
Author(s) -
Wang WenMing,
Wu Chao,
Jin HongZhong
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13857
Subject(s) - microvesicles , psoriasis , exosome , atopic dermatitis , medicine , immunology , melanoma , microrna , disease , inflammation , endocytic cycle , cancer research , biology , pathology , biochemistry , gene , endocytosis , receptor
Exosomes are membrane vesicles of endocytic origin that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Moreover, we emphasize the involvement of changes in exosome cargo in the regulation of these diseases.