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Increased expression of PD 1 and CD 39 on CD 3 + CD 4 + skin T cells in the elderly
Author(s) -
Zuelgaray Elina,
Boccara David,
Ly Ka So Sophie,
Boismal Françoise,
Mimoun Maurice,
Bagot Martine,
Bensussan Armand,
Bouaziz JeanDavid,
Michel Laurence
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13842
Subject(s) - immune system , immunology , downregulation and upregulation , ageing , flow cytometry , microbiology and biotechnology , t lymphocyte , biology , medicine , gene , biochemistry
Normal ageing is associated with an impaired systemic immune response contributing to an increased susceptibility to infectious diseases. The aim of this study was to compare the lymphocyte phenotype in human skin from old and young healthy subjects. Skin samples from donors were used for explant cultures before flow cytometric analysis. Our results depicted a higher proportion of CD 4 + and a lower proportion of CD 8 + among CD 3 + T cells, a decreased proportion of CD 45 RA + naive T cells (3.5 ± 1.9% vs 22.9 ± 11.1%, P ≤ 0.007) and an upregulation of the expression of CD 39 and PD 1 on CD 3 + CD 4 + T cells (25.1 ± 8.5% vs 12.5 ± 8.5%, P ≤ 0.003, 68.8 ± 11.6% vs 50.0 ± 11.3%, P ≤ 0.01, respectively) in the skin of old subjects. These findings could explain a reduced generation of long‐lived memory T cells and an impaired antitumoral response in the skin of the elderly.