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3‐ O ‐Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress
Author(s) -
Katsuyama Yushi,
Taira Norihisa,
Tsuboi Tatsuya,
Yoshioka Masato,
Okano Yuri,
Masaki Hitoshi
Publication year - 2019
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13820
Subject(s) - oxidative stress , dry skin , dryness , chemistry , ascorbic acid , human skin , biophysics , dermatology , biochemistry , medicine , immunology , biology , food science , genetics
Abstract Skin sensitivity is a serious problem for many people, and it can be induced by various factors such as UV irradiation, physical and mental stresses, air pollution, dry air and so on. Skin dryness triggered by UV and dry air is one of the most important causes inducing the development of sensitive skin, and it has been reported that oxidative stress contributes to skin dryness. In this study, we investigated whether treatment with 3‐ O ‐laurylglyceryl ascorbate ( VC ‐3 LG ), which is an amphipathic ascorbic acid derivative, can suppress the development of sensitive skin. The results demonstrate that VC ‐3 LG restores the expression levels of interleukin‐1α, nerve growth factor and matrix metalloprotease‐9 in the dry skin models of reconstructed human epidermal equivalents ( RHEE s) and in H 2 O 2 ‐treated keratinocytes. In addition, VC ‐3 LG suppresses the dendrite elongation of nerve cells induced in RHEE s by dry skin conditions and by H 2 O 2 treatment of keratinocytes. Therefore, we consider that treatment of the skin with VC ‐3 LG is an effective approach to improve the development of sensitive skin.