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Molecular pathogenesis of cutaneous lymphomas
Author(s) -
Stadler Rudolf,
Stranzenbach René
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13701
Subject(s) - mycosis fungoides , pathogenesis , lymphoma , cutaneous t cell lymphoma , immunology , t cell , medicine , biology , cancer research , cytokine , immune system
Primary cutaneous T‐cell lymphoma ( CTCL ) comprises the second most common group of extra‐nodal non‐Hodgkin's lymphoma. They represent incurable primary extra‐nodal lymphomas of major T cells, uniformly present in the skin with 1%‐2% risk of systemic dissemination in mycosis fungoides ( MF ), which represents the most common subtype of CTCL . In general, long‐term antigen stimulation is thought, through key cytokine signalling pathways, to induce an inflammatory response with T‐cell proliferation, leading to a clonal malignant T cell with continuous expansion. However, in recent years, using data harvested from high‐throughput transcriptional profiling, substantial advances in the understanding of the molecular pathogenesis were made to understand the complex pathogenesis of CTCL . In this review, the actual data are summarised.