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Protein kinases involved in epidermal barrier formation: The AKT family and other animals
Author(s) -
Rogerson Clare,
O'Shaughnessy Ryan F. L.
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13696
Subject(s) - epidermis (zoology) , microbiology and biotechnology , barrier function , kinase , skin barrier , function (biology) , biology , protein kinase b , biophysics , chemistry , phosphorylation , anatomy , medicine , dermatology
Abstract Formation of a stratified epidermis is required for the performance of the essential functions of the skin; to act as an outside‐in barrier against the access of microorganisms and other external factors, to prevent loss of water and solutes via inside‐out barrier functions and to withstand mechanical stresses. Epidermal barrier function is initiated during embryonic development and is then maintained throughout life and restored after injury. A variety of interrelated processes are required for the formation of a stratified epidermis, and how these processes are both temporally and spatially regulated has long been an aspect of dermatological research. In this review, we describe the roles of multiple protein kinases in the regulation of processes required for epidermal barrier formation.