The effects of vitamin K1 and vitamin K2 on the proliferation, cytokine production and regulatory T‐cell frequency in peripheral blood mononuclear cells of paediatric atopic dermatitis patients | Zendy

Meng Kehan | Zendy; Xu Wencheng | Zendy; Miura Taro | Zendy; Suzuki Shunsuke | Zendy; Chiyotanda Masako | Zendy; Tanaka Sachiko | Zendy; Sugiyama Kentaro | Zendy; Kawashima Hisashi | Zendy; Hirano Toshihiko | Zendy

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The effects of vitamin K1 and vitamin K2 on the proliferation, cytokine production and regulatory T‐cell frequency in peripheral blood mononuclear cells of paediatric atopic dermatitis patients

Author(s) -

Meng Kehan,

Xu Wencheng,

Miura Taro,

Suzuki Shunsuke,

Chiyotanda Masako,

Tanaka Sachiko,

Sugiyama Kentaro,

Kawashima Hisashi,

Hirano Toshihiko

Publication year - 2018

Publication title -

experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.108

H-Index - 96

eISSN - 1600-0625

pISSN - 0906-6705

DOI - 10.1111/exd.13671

Subject(s) - peripheral blood mononuclear cell , immunology , cytokine , medicine , atopic dermatitis , cell growth , t cell , in vitro , chemistry , immune system , biochemistry

We estimated the pharmacological efficacy of vitamin K 1 ( VK 1 ) and VK 2 on the mitogen‐activated peripheral blood mononuclear cells ( PBMC s) of paediatric atopic dermatitis ( AD ) patients. VK 2 suppressed the in vitro proliferation of T‐cell mitogen‐activated PBMC s of AD patients. In contrast, VK 1 had little effect on the PBMC proliferation. The IL ‐2 production from the activated PBMC s of AD patients significantly increased ( P < .05), while the production significantly decreased by 100 μmol L −1 VK 2 ( P < .01). In addition, 100 μmol L −1 VK 2 reduced the percentage of CD 4+ and CD 4+ CD 25+ cells in PBMC s. These results suggest that VK 2 can modulate T‐cell function in PBMC s of AD patients.

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