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The effects of vitamin K1 and vitamin K2 on the proliferation, cytokine production and regulatory T‐cell frequency in peripheral blood mononuclear cells of paediatric atopic dermatitis patients
Author(s) -
Meng Kehan,
Xu Wencheng,
Miura Taro,
Suzuki Shunsuke,
Chiyotanda Masako,
Tanaka Sachiko,
Sugiyama Kentaro,
Kawashima Hisashi,
Hirano Toshihiko
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13671
Subject(s) - peripheral blood mononuclear cell , immunology , cytokine , medicine , atopic dermatitis , cell growth , t cell , in vitro , chemistry , immune system , biochemistry
We estimated the pharmacological efficacy of vitamin K 1 ( VK 1 ) and VK 2 on the mitogen‐activated peripheral blood mononuclear cells ( PBMC s) of paediatric atopic dermatitis ( AD ) patients. VK 2 suppressed the in vitro proliferation of T‐cell mitogen‐activated PBMC s of AD patients. In contrast, VK 1 had little effect on the PBMC proliferation. The IL ‐2 production from the activated PBMC s of AD patients significantly increased ( P < .05), while the production significantly decreased by 100 μmol L −1 VK 2 ( P < .01). In addition, 100 μmol L −1 VK 2 reduced the percentage of CD 4+ and CD 4+ CD 25+ cells in PBMC s. These results suggest that VK 2 can modulate T‐cell function in PBMC s of AD patients.