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Preliminary observations of a new approach to tissue repair: Peripheral blood mononuclear cells in platelet‐rich plasma injected into skin graft area
Author(s) -
Orlandi Catuscia,
Bondioli Elena,
Venturi Michela,
Melandri Davide
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13552
Subject(s) - platelet rich plasma , medicine , peripheral blood mononuclear cell , wound healing , regeneration (biology) , platelet , perioperative , tissue repair , pathology , surgery , immunology , biomedical engineering , chemistry , biology , microbiology and biotechnology , biochemistry , in vitro
Our purpose was accelerating the physiologic wound healing, stimulating tissue regeneration and the reparative tissue processes in resistant skin ulcers as in a case of an erosive lichen planus of the soles and after a surgical treatment as for severe Darier disease. The challenge was to establish an effective therapy to enhance tissue healing by the injection of a mixture of peripheral blood mononuclear cells (PB‐MNCs) and platelet‐rich plasma (PRP) into a skin autograft area. This new perioperative biotechnological approach enriches PRP with the effects of PB‐MNCs. It offers a novel advanced strategy that could become an ideal biologic blood‐derived therapy, whose components are entirely autologous and produced by a protocol independent by the operator.