Preliminary observations of a new approach to tissue repair: Peripheral blood mononuclear cells in platelet‐rich plasma injected into skin graft area

Our purpose was accelerating the physiologic wound healing, stimulating tissue regeneration and the reparative tissue processes in resistant skin ulcers as in a case of an erosive lichen planus of the soles and after a surgical treatment as for severe Darier disease. The challenge was to establish an effective therapy to enhance tissue healing by the injection of a mixture of peripheral blood mononuclear cells (PB‐MNCs) and platelet‐rich plasma (PRP) into a skin autograft area. This new perioperative biotechnological approach enriches PRP with the effects of PB‐MNCs. It offers a novel advanced strategy that could become an ideal biologic blood‐derived therapy, whose components are entirely autologous and produced by a protocol independent by the operator.