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Homeobox transcription factor DLX 4 is not necessary for skin development and homeostasis
Author(s) -
Bhattacharya Shreya,
Duverger Olivier,
Brooks Stephen R.,
Morasso Maria I.
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13503
Subject(s) - homeobox , transcription factor , hair follicle , epidermis (zoology) , biology , dlx5 , homeobox a1 , microbiology and biotechnology , homeostasis , embryonic stem cell , gene , embryo , embryogenesis , anatomy , genetics
Dlx4 is a member of a family of homeobox genes with homology to Drosophila distal‐less ( dll ) gene. We show that Dlx4 expression pattern partially overlaps with its cis‐linked gene Dlx3 during mouse development as well as in neonatal and adult skin. In mice, Dlx4 is expressed in the branchial arches, embryonic limbs, digits, nose, hair follicle and in the basal and suprabasal layers of mouse interfollicular epidermis. We show that inactivation of Dlx4 in mice did not result in any overtly gross pathology. Skin development, homeostasis and response to TPA treatment were similar in mice with loss of Dlx4 compared to wild‐type counterparts.