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Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias
Author(s) -
Sundberg John P.,
Hordinsky Maria K.,
Bergfeld Wilma,
Lenzy Yolanda M.,
McMichael Amy J.,
Christiano Angela M.,
McGregor Tracy,
Stenn Kurt S.,
Sivamani Raja K.,
Pratt Craig Herbert,
King Lloyd E.
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13495
Subject(s) - medicine , dermatology , scarring alopecia , hair growth , hair loss , pathology , physiology , scalp
Primary cicatricial alopecias ( PCA s) are a group of skin diseases in which there is progressive and permanent destruction of hair follicles followed by replacement with fibrous tissue. Unfortunately, by the time patients seek clinical evaluation of their hair loss, the skin is already inflamed and/or scarred, so there is little hope for a return to their normal hair growth pattern. Clinical and basic science investigations are now focusing on three forms of human PCA : lichen planopilaris ( LPP ), frontal fibrosing alopecia ( FFA ) and central centrifugal cicatricial alopecia ( CCCA ). Transcriptome, lipidome and other new technologies are providing new insight into the pathogenesis of some of these diseases that are being validated and further investigated using spontaneous and genetically engineered mouse models.