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Reversine inhibits MMP ‐1 and MMP ‐3 expressions by suppressing of ROS / MAPK / AP ‐1 activation in UV ‐stimulated human keratinocytes and dermal fibroblasts
Author(s) -
Kim JeongMi,
Kim Sun young,
Noh EunMi,
Song HyunKyung,
Lee GuemSan,
Kwon KangBeom,
Lee YoungRae
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13494
Subject(s) - matrix metalloproteinase , mapk/erk pathway , reactive oxygen species , chemistry , microbiology and biotechnology , intracellular , transcription factor , cytokine , signal transduction , immunology , biochemistry , biology , gene
UVB has been shown to stimulate the generation of reactive oxygen species ( ROS ), which subsequently results in the activation of various intracellular signalling pathways and transcription factors ( AP ‐1, NF ‐κB). These transcription factors are regulated by MAPK s, which increase cytokine and MMP expression. We examined the preventive effects of reversine on MMP ‐1 and MMP ‐3 expressions in NHEK s and NHDF s exposed to UVB irradiation. Also, we confirmed that reversine decreased pro‐inflammatory cytokine expression in NHEK s. The mechanism underlying the MMP inhibitory effects of reversine occurred via the suppression of UVB ‐induced ROS generation and MAPK / AP ‐1 activation. Therefore, reversine is an effective therapeutic candidate for preventing skin photoageing.