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Characterization of the facial microbiome in twins discordant for rosacea
Author(s) -
Zaidi Asifa K.,
Spaunhurst Katrina,
Sprockett Daniel,
Thomason Yolandas,
Mann Margaret W.,
Fu Pingfu,
Ammons Christine,
Gerstenblith Meg,
Tuttle Marie S.,
Popkin Daniel L.
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13491
Subject(s) - rosacea , microbiome , dermatology , medicine , biology , computational biology , evolutionary biology , genetics , acne
Previously, we determined that genetic and environmental factors contributed equally towards rosacea in twins. To assess an environmental factor, we characterized the malar cheek bacterial microbiome from twins discordant for rosacea. We found no significant difference in facial microbiome alpha and beta diversity between related twins discordant for rosacea. However, the relative percentage abundance of Gordonia and Geobacillus , low‐abundant genera, was positively and negatively associated with rosacea severity, respectively. Our data demonstrate a significant correlation between facial microbiome and severity of rosacea in genetically matched twins and importantly that overall microbiome composition is largely unchanged.