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BRAF mutations might be more common than supposed in vulvar melanomas
Author(s) -
Wylomanski Sophie,
Denis Marc G.,
Théoleyre Sandrine,
Bouquin Réjane,
Vallée Audrey,
Knol AnneChantal,
SaintJean Mélanie,
Peuvrel Lucie,
Dréno Brigitte,
Quéreux Gaëlle
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13472
Subject(s) - neuroblastoma ras viral oncogene homolog , medicine , melanoma , dermatology , mutation , oncology , prospective cohort study , mucosal melanoma , vulva , cancer research , cancer , kras , biology , gene , genetics , colorectal cancer
Data on BRAF , NRAS and KIT mutations are scarce in patients with vulvo‐vaginal melanomas and are associated with important therapeutic issues. We investigated their prevalence in a cohort of patients with female lower genital tract melanomas between 2003 and 2017. Of the 22 patients, 5 (22.7%) harboured a BRAF mutation, which was much higher than the rate of 5% reported in the literature. One patient, who was tested negative on the primary melanoma, had a NRAS mutation in a cutaneous metastasis. Our data provide a rationale for prospective and repeated mutations testing in female lower genital tract melanomas.