Premium
Rosacea and its association with enteral microbiota in Korean females
Author(s) -
Nam JaeHui,
Yun Yeojun,
Kim HanSaem,
Kim HanNa,
Jung Ho Joo,
Chang Yoosoo,
Ryu Seungho,
Shin Hocheol,
Kim HyungLae,
Kim WonSerk
Publication year - 2018
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13398
Subject(s) - rosacea , metagenomics , biology , gut flora , genus , microbiome , medicine , microbiology and biotechnology , zoology , immunology , bioinformatics , genetics , gene , acne
Rosacea is a chronic inflammatory dermatosis affecting the face and eyes. An association between systemic comorbidities and rosacea has been reported, but the link to enteral microbiota is uncertain. We aimed to investigate the link between rosacea and enteral microbiota. A cross‐sectional study was performed in a sample of Korean women who participated in a health check‐up programme at the Kangbuk Samsung Hospital Health Screening Center between 23 June 2014 and 5 September 2014. The gut microbiome was evaluated by 16S rRNA gene and metagenome sequence analyses. A total of 12 rosacea patients and 251 controls were enrolled. We identified links between rosacea and several changes in gut microbiota: reduced abundance of Peptococcaceae family unknown genus , Methanobrevibacter (genus) , Slackia (genus) , Coprobacillus (genus) , Citrobacter (genus), and Desulfovibrio (genus), and increased abundance of Acidaminococcus (genus) , Megasphaera (genus) , and Lactobacillales order unknown family unknown genus. A link between rosacea and enteral microbiota was observed in this metagenomic study. A large and elaborate study is needed to confirm these findings and to elucidate the mechanisms involved.