Premium
Higher plasma leptin is associated with higher risk of androgenetic alopecia in men
Author(s) -
Yang ChaoChun,
Chung PeiLun,
Lin LiYu,
Hughes Michael W.,
Tsai YauSheng
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13369
Subject(s) - leptin , odds ratio , medicine , logistic regression , endocrinology , multivariate analysis , obesity
In addition to genetics and androgens, novel factors could play a role in androgenetic alopecia ( AGA ). This study aims to investigate the association between plasma leptin level with the risk and severity of AGA in men. Forty‐eight subjects were enrolled including 29 AGA and 19 non‐ AGA subjects. The plasma leptin level was significantly higher in AGA subjects, compared to non‐ AGA subjects (4.45 vs 2.76 ng/ mL , P <.05). A higher plasma leptin levels were positively correlated with the risk of developing AGA in multivariate logistic analysis (odds ratio=2.77, P <.05). Leptin from the circulation might impact the development of AGA .