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The Kollias legacy: Skin autofluorescence and beyond
Author(s) -
Bargo Paulo R.,
Doukas Apostolos,
González Salvador,
Me Gopinathan,
Pappas Apostolos,
Ruvolo Eduardo C.,
Stamatas Georgios N.
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13330
Subject(s) - photoaging , autofluorescence , dermis , epidermis (zoology) , skin aging , dermatology , skin cancer , medicine , fluorescence , sun exposure , pathology , chemistry , cancer , anatomy , optics , physics
Abstract In a paper published at the J Invest Dermatol in 1998 Nik Kollias and coworkers described distinct changes in skin native fluorescence associated with skin aging and photoaging, using in vivo fluorescence excitation spectroscopy. The assignment of the 295 nm band to tryptophan fluorescence had a profound significance influencing many later studies from multiple groups. The reproducible changes in skin native fluorescence suggested that aging causes predictable alterations in both the epidermis and the dermis, whereas chronic UV exposure induces the appearance of new fluorophores. This seminal, but insufficiently widely appreciated work deserves re‐examination as it points to important horizons in future experimental dermatology, such as cancer diagnostics, diabetes, wound healing, and understanding skin aging and photoaging mechanisms.