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A pulmonary metastatic model of murine melanoma assessed by magnetic resonance imaging
Author(s) -
Numata Takafumi,
Kiryu Shigeru,
Maeda Tatsuo,
Egusa Chizu,
Tsuboi Ryoji,
Harada Kazutoshi
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13327
Subject(s) - medicine , pinna , melanoma , metastasis , magnetic resonance imaging , lung , nodule (geology) , pathology , metastatic melanoma , radiology , cancer , cancer research , surgery , biology , paleontology
Immune checkpoint inhibitors and kinase inhibitors have improved prognosis of malignant melanoma ( MM ) patients. However, these therapies cannot completely overcome the metastasis of MM . Thus, development of new therapy against metastasis should be required. A first step towards this goal, the aim of this study, is to establish a model of pulmonary metastasis from primary cutaneous MM and a monitoring system. B16‐F10, a murine melanoma cell line, was subcutaneously injected into the pinna of mice. The pinna was excised when the lesion was detected. A metastatic nodule on T2‐weighted imaging was detected 4 weeks after resection of the pinna. Lung metastases were observed in 37.5% (6/16) of the specimens. We established a novel murine model of the high pulmonary metastasis of MM . The MRI was useful for observations of the growth of the metastatic lesions in the lungs without dissection.