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Infundibular protein and RNA microarray analyses from affected and clinically non‐affected scalp in male androgenetic alopecia patients
Author(s) -
Vogt Annika,
Pfannes Eva K. B.,
Fimmel Sabine,
Hadam Sabrina,
Andruck Annette,
Kottner Jan,
BlumePeytavi Ulrike
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13326
Subject(s) - scalp , infundibulum , hair follicle , rna , biology , rna extraction , dermal papillae , endocrinology , medicine , dermatology , gene , anatomy , genetics
Non‐invasive sample collection methods could facilitate clinical research on hair diseases. In an exploratory experimental study on six male volunteers with untreated androgenetic alopecia ( AGA ), Hamilton‐Norwood stage III v‐ IV , skin surface and infundibular protein as well as RNA extracts from plucked hair follicles were analyzed from frontal skin, vertex and clinically unaffected occiput. Slightly increased levels of inflammatory markers were only found in AGA ‐affected scalp skin and infundibulum, not in RNA from plucked hair follicles. RNA expression profiles point towards differential expression of genes involved in hair cycle regulation, hair keratin production, but also RNA methylation and ion channel regulation.