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Filaggrin has evolved from an “S100 fused‐type protein” ( SFTP ) gene present in a common ancestor of amphibians and mammals
Author(s) -
Mlitz Veronika,
Hussain Tajamul,
Tschachler Erwin,
Eckhart Leopold
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13317
Subject(s) - filaggrin , biology , xenopus , gene , atopic dermatitis , genetics , ichthyosis vulgaris , immunology
The expression of filaggrin in differentiated keratinocytes and the association of filaggrin mutations with ichthyosis vulgaris and atopic dermatitis suggest that this prototypical member of the S100 fused‐type protein ( SFTP ) family plays a key role in the epidermal barrier to the environment. Here, we report that SFTP genes are present not only in amniotes but also in amphibians. Four SFTP s are expressed in the skin of the frog Xenopus laevis . The results of this study indicate that filaggrin has evolved from an ancestral SFTP that may have contributed to skin modifications during the evolutionary transition to terrestrial life.