z-logo
Premium
Filaggrin has evolved from an “S100 fused‐type protein” ( SFTP ) gene present in a common ancestor of amphibians and mammals
Author(s) -
Mlitz Veronika,
Hussain Tajamul,
Tschachler Erwin,
Eckhart Leopold
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13317
Subject(s) - filaggrin , biology , xenopus , gene , atopic dermatitis , genetics , ichthyosis vulgaris , immunology
The expression of filaggrin in differentiated keratinocytes and the association of filaggrin mutations with ichthyosis vulgaris and atopic dermatitis suggest that this prototypical member of the S100 fused‐type protein ( SFTP ) family plays a key role in the epidermal barrier to the environment. Here, we report that SFTP genes are present not only in amniotes but also in amphibians. Four SFTP s are expressed in the skin of the frog Xenopus laevis . The results of this study indicate that filaggrin has evolved from an ancestral SFTP that may have contributed to skin modifications during the evolutionary transition to terrestrial life.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here