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Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration
Author(s) -
Kishimoto Yu,
Asakawa Sanki,
Sato Taiki,
Takano Takayuki,
Nakajyo Takahisa,
Mizuno Natsumi,
Segawa Ryosuke,
Yoshikawa Takeo,
Hiratsuka Masahiro,
Yanai Kazuhiko,
Ohtsu Hiroshi,
Hirasawa Noriyasu
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13315
Subject(s) - histamine , histidine decarboxylase , monocyte , inflammation , microbiology and biotechnology , histamine n methyltransferase , knockout mouse , chemotaxis , chemistry , infiltration (hvac) , receptor , biology , endocrinology , immunology , enzyme , histamine h2 receptor , biochemistry , materials science , histidine , composite material , antagonist
Histamine regulates various inflammatory reactions. We have reported that the expression of histidine decarboxylase ( HDC ) was induced by subcutaneous implantation of nickel (Ni) wire. However, the source and functions of histamine in Ni elution and Ni wire‐induced inflammation have not been completely studied. We aimed to elucidate the effects of de novo synthesized histamine on leucocyte infiltration and Ni elution. Implantation of Ni wire induced an increase in the Ni ion content of the surrounding tissues and serum and in the mRNA levels of HDC , a histamine‐producing enzyme, macrophage inflammatory protein‐2 ( MIP ‐2), a chemoattractant for neutrophils, and monocyte chemoattractant protein‐1 ( MCP ‐1), a chemoattractant for monocytes. The Ni wire induced HDC expression even in mast cell‐deficient WBB 6F1‐W/ W V mice. In HDC knockout ( HDC KO ) mice, the Ni wire‐induced increase in MIP ‐2 mRNA expression was significantly higher than that in wild‐type mice but not MCP ‐1. MIP ‐2 expression was enhanced in histamine H2 receptor knockout (H2R KO ) mice but not in WBB 6F1‐W/ W V mice. Histamine inhibited NiCl 2 ‐induced MIP ‐2 mRNA expression in mouse bone marrow‐derived macrophages ( BMDM s) obtained from wild‐type mice; this inhibition was not observed in BMDM s from H2R KO mice. Ni elution increased in HDC KO mice, in which leucocyte infiltration also increased, and was suppressed in mice treated with neutrophil‐specific antibody. These results suggest that the Ni wire induced HDC expression in non‐mast cells and that, in the chronic phase of inflammation, endogenous histamine reduced Ni elution, probably through regulation of MIP ‐2 expression and neutrophil migration.