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Excessive angiogenesis associated with psoriasis as a cause for cardiovascular ischaemia
Author(s) -
Malecic Nina,
Young Helen S.
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13310
Subject(s) - psoriasis , angiogenesis , medicine , pathogenesis , comorbidity , population , disease , pathological , vascular endothelial growth factor , dermatology , immunology , vegf receptors , pathology , environmental health
Psoriasis, a common disease affecting 2%‐3% of the UK population, produces significant impairment of quality of life and is an immense burden on sufferers and their families. Psoriasis is associated with significant cardiovascular comorbidity and the metabolic syndrome. Angiogenesis, a relatively under‐researched component of psoriasis, is a key factor in pathogenesis of psoriasis and also contributes to the development of atherosclerosis. Vascular endothelial growth factor ( VEGF ) is a well‐established mediator of pathological angiogenesis which is upregulated in psoriasis. It is possible that, in patients with psoriasis, cutaneous angiogenesis may be both a marker for systemic vascular pathology and a novel therapeutic target. In this viewpoint study, the role of VEGF ‐mediated angiogenesis as a cause for cardiovascular events in patients with psoriasis is explored.