Overexpression of  AQP 3 and  AQP 10 in the skin exacerbates psoriasiform acanthosis | Zendy

Soler David C. | Zendy; Young Andrew E. | Zendy; Griffith Alexis D. | Zendy; Fu Ping fu | Zendy; Cooper Kevin D. | Zendy; McCormick Thomas S. | Zendy; Popkin Daniel L. | Zendy

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Overexpression of AQP 3 and AQP 10 in the skin exacerbates psoriasiform acanthosis

Author(s) -

Soler David C.,

Young Andrew E.,

Griffith Alexis D.,

Fu Ping fu,

Cooper Kevin D.,

McCormick Thomas S.,

Popkin Daniel L.

Publication year - 2017

Publication title -

experimental dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.108

H-Index - 96

eISSN - 1600-0625

pISSN - 0906-6705

DOI - 10.1111/exd.13307

Subject(s) - aquaporin 3 , downregulation and upregulation , acanthosis , aquaporin , epidermis (zoology) , dermatology , psoriasis , pathogenesis , medicine , cancer research , biology , immunology , chemistry , hyperkeratosis , physiology , genetics , gene , anatomy

We previously observed that aquaporin‐3 and aquaporin‐10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses , 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP 3/ AQP 10 in mice using the human K1 promoter. Combining imiquimod with detergent‐containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP 3 or AQP 3 and AQP 10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.

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