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Overexpression of AQP 3 and AQP 10 in the skin exacerbates psoriasiform acanthosis
Author(s) -
Soler David C.,
Young Andrew E.,
Griffith Alexis D.,
Fu Ping fu,
Cooper Kevin D.,
McCormick Thomas S.,
Popkin Daniel L.
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13307
Subject(s) - aquaporin 3 , downregulation and upregulation , acanthosis , aquaporin , epidermis (zoology) , dermatology , psoriasis , pathogenesis , medicine , cancer research , biology , immunology , chemistry , hyperkeratosis , physiology , genetics , gene , anatomy
We previously observed that aquaporin‐3 and aquaporin‐10 are upregulated in the epidermis of hand dermatitis patients (Med. Hypotheses , 84, 2015, 498). To address the functional relevance of this upregulation, we overexpressed AQP 3/ AQP 10 in mice using the human K1 promoter. Combining imiquimod with detergent‐containing water challenge, a common trigger in hand and other dermatitis, resulted in an increase in acanthosis in mice overexpressing AQP 3 or AQP 3 and AQP 10. Aquaporin overexpression also drove a trend towards greater weight loss in these animals. These data support a role for cutaneous aquaporins in the pathogenesis of dermatitis and as a potential target in their treatment.