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Niacinamide leave‐on formulation provides long‐lasting protection against bacteria in vivo
Author(s) -
Mathapathi Mruthyunjaya Swamy,
Mallemalla Prathyusha,
Vora Shilpa,
Iyer Vidula,
Tiwari Jyoti Kumar,
Chakrabortty Amit,
Majumdar Amitabha
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13285
Subject(s) - niacinamide , antimicrobial peptides , antimicrobial , innate immune system , in vivo , skin infection , immune system , melanin , cosmeceutical , pharmacology , biology , immunology , medicine , bacteria , microbiology and biotechnology , staphylococcus aureus , biochemistry , nicotinamide , enzyme , genetics
Abstract Antimicrobial peptides ( AMP s) form a part of the skin's innate immune system. Their primary activity is to provide antimicrobial benefits and hence protect from infections. AMP s that are present on human skin include psoriasin (S100A7), RN ase 7, lysozyme, LL ‐37 and defensins. Niacinamide is a well‐known cosmetic ingredient that has been used traditionally for multiple skin benefits. Recent data indicate that niacinamide treatment can boost AMP s in human gut epithelial cells and in neutrophils. Treatment with niacinamide in mice also provided protection from skin infections by enhancing AMP s. In this article, we find that treatment with niacinamide formulation provides long‐lasting protection against bacteria, potentially through the activation of an AMP response.