Premium
Body regions have an impact on the collagen/elastin index of the skin measured by non‐invasive in vivo vertical two‐photon microscopy
Author(s) -
Czekalla Carolin,
Schönborn Karl Heinz,
Döge Nadine,
Jung Sora,
Darvin Maxim E.,
Lademann Jürgen,
Meinke Martina C.
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13283
Subject(s) - elastin , in vivo , autofluorescence , microscopy , two photon excitation microscopy , biophysics , optical microscope , pathology , chemistry , materials science , anatomy , biomedical engineering , optics , medicine , biology , composite material , scanning electron microscope , fluorescence , physics , microbiology and biotechnology
It is known that the collagen and elastin fibre structures are changing with age. There is little knowledge about the influence of body area as these investigations have been limited for ethical reasons, so far. Thus, modified non‐invasive two‐photon microscopy was used providing vertical optical sections of second harmonic generation and autofluorescence to calculate the collagen‐to‐elastin ratio and its alterations depending on the investigated body site in vivo. The results of this study indicate that the impact of different body areas could be higher than the influence of age and should be considered in future studies.