Premium
The expanding microRNA world in psoriasis
Author(s) -
Sonkoly Enikö
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13275
Subject(s) - psoriasis , microrna , transcriptome , inflammation , biology , signalling pathways , bioinformatics , gene , computational biology , medicine , immunology , genetics , gene expression
Psoriasis skin lesions are characterized by dramatic changes in the transcriptome, reflecting altered activity of multiple signalling pathways in resident and infiltrating cells. mi RNA s are small non‐coding RNA s that have a large impact on cellular functions by regulating multiple genes simultaneously, and they have been shown to play key roles in skin homoeostasis and inflammation. In this commentary to the review article “Micro RNA s in Psoriasis: Immunological Functions and Potential Biomarkers” by Liu et al., the role of mi RNA s in psoriasis and their diagnostic and therapeutic potential are discussed and remaining unanswered questions are highlighted.