Premium
Galanin contributes to ultraviolet irradiation‐induced inflammation in human skin
Author(s) -
Lee Min Jung,
Oh JangHee,
Park ChiHyun,
Kim Kyu Han,
Lee Dong Hun,
Chung Jin Ho
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13268
Subject(s) - galanin , neuropeptide , human skin , epidermis (zoology) , inflammation , endocrinology , matrix metalloproteinase , medicine , receptor , chemistry , biology , anatomy , genetics
Abstract Exposure of the skin to ultraviolet ( UV ) irradiation causes various consequences such as inflammation and photoageing. Galanin is an active neuropeptide expressed widely in the central nervous system and peripheral tissues including the skin. Galanin promotes or inhibits inflammation in a context‐dependent manner, but its role in UV irradiation‐induced responses in human skin was still unknown. UV irradiation induced a substantial expression of galanin in primary epidermal keratinocytes in vitro and in human epidermis in vivo. Galanin knock‐down by si RNA transfection markedly inhibited UV irradiation‐induced expression of matrix metalloproteinase ( MMP )‐1, interleukin ( IL )‐1β, IL ‐6 and cyclooxygenase ( COX )‐2. Moreover, si RNA ‐mediated knock‐down of GAL 2 , a principal galanin receptor in the skin, led to a considerable decrease in these mediators in keratinocytes. Collectively, our findings suggest that galanin is an important messenger between the neuroendocrine system and UV irradiation‐damaged skin.