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Roles of micro RNA s in psoriasis: Immunological functions and potential biomarkers
Author(s) -
Liu Qing,
Wu DingHong,
Han Ling,
Deng JingWen,
Zhou Li,
He Rui,
Lu ChuanJian,
Mi QingSheng
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13249
Subject(s) - psoriasis , rna , microrna , immune system , non coding rna , gene silencing , rna silencing , long non coding rna , rna interference , immunology , biology , cancer research , medicine , gene , genetics
Micro RNA s (mi RNA s) are small non‐coding RNA molecules, which function in RNA silencing and post‐transcriptional regulation of gene expression. Psoriasis is an inflammatory skin disease characterized by the dysfunction of keratinocytes, with the immune dysregulation. We reviewed the recent studies on the roles of mi RNA s in psoriasis and showed that mi RNA s play key roles in psoriasis, including the regulation of hyperproliferation, cytokine and chemokine production in keratinocyte, as well as mediating immune dysfunction in psoriasis. Furthermore, mi RNA s, particularly, circulating mi RNA s may serve as novel biomarkers for diagnosis, monitoring therapy response and reflecting the disease severity. Thus, targeting specific mi RNA s may be used to develop new therapeutic methods for psoriasis.