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Author(s) -
Lowell A. Goldsmith
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13242
Subject(s) - computer science , citation , information retrieval , world wide web
Hair length is related to the duration of the anagen phase of the hair cycle. Mice with the Angora mutation have long hair because of the absence of the Fibroblast Growth Factor-5 (FGF-5). FGF-5 has a role in the anagen to categen transition. Foley and colleagues have determined that parathyroid hormone related protein (PTHrP) and its receptor have a role in regulating the transition of anagen to catagen independent of FGF-5 (p. 715). Overexpression of this protein caused hairs to be 30^40% shorter. Inhibitors of PTHrP will be available since this protein is associated with the humoral hypercalcemia of malignancy, and may make human hair grow longer.