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Contact allergens induce CD8 + T cell‐derived interleukin 10 that appears dispensable for regulation of contact hypersensitivity
Author(s) -
Dolch Anja,
Kunz Stefanie,
Dorn Britta,
Roers Axel,
Martin Stefan F.,
Jakob Thilo
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13237
Subject(s) - cd8 , immunology , allergic contact dermatitis , cytotoxic t cell , effector , t cell , interleukin 4 , contact dermatitis , phenotype , biology , antigen , microbiology and biotechnology , chemistry , allergy , immune system , in vitro , gene , genetics
Interleukin 10 ( IL ‐10) has been implied in the regulation of allergic contact dermatitis. Using transcriptional reporter mice we analyzed cellular sources of IL ‐10 during contact hypersensitivity ( CHS ) and identified IL ‐10 expressing CD 8 + T cells in the skin that are antigen‐specific, display PD ‐1, an effector memory phenotype, and IL ‐10 expression comparable to that of CD 4 + T cells. However, in mice with a selective IL ‐10 deficiency in CD 8 + T cells CHS responses were comparable to that of controls, even in the absence of CD 4 + cells, suggesting that CD 8 + T cell‐derived IL ‐10 does not contribute significantly to the resolution of CHS responses.