Premium
The genetic basis of pigmentation in alopecia areata
Author(s) -
Zheng Min,
Ren Yunqing
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13217
Subject(s) - alopecia areata , genome wide association study , hair loss , genetics , cabello , dermatology , biology , genetic linkage , gene , genetic association , population , pigmentation disorder , medicine , genotype , single nucleotide polymorphism , scalp , environmental health
Alopecia areata (AA) is a common hair loss disorder characterized by discrete, well demarcated areas of non‐scarring terminal hair alopecia, with the calculated lifetime risk of ~2%. In past decades, linkage and GWA studies have implicated dozens of susceptibility genes/loci that are linked to the development of AA. Fischer et al performed a genome‐wide CNV analysis of 585 AA patients and 1,340 controls in a European population. This is the first genome‐wide study of CNV to be performed in AA samples, and the association finding in the MCHR2 gene region further underscores the potential role of pigmentation in AA development.