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The TRAIL to acne pathogenesis: let's focus on death pathways
Author(s) -
Melnik Bodo C.
Publication year - 2017
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.13169
Subject(s) - acne , mtorc1 , pathogenesis , pi3k/akt/mtor pathway , isotretinoin , signalling , medicine , cancer research , signal transduction , biology , immunology , dermatology , microbiology and biotechnology
Abstract This hypothesis presents acne as a PI3K‐Akt‐mTORC1‐driven pro‐survival disease of the sebaceous follicle with impaired TRAIL‐mediated death signalling. It is predicted that anti‐acne agents such as isotretinoin enhance death signalling and thereby readjust the disturbed balance of pro‐survival and death signalling of the sebaceous follicle in acne vulgaris. For this purpose, immortalized sebocyte cultures are regarded as inapproproate models to study the key features of acne pathogenesis.