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Hmga2 is dispensable for cutaneous squamous cell carcinoma
Author(s) -
White Andrew,
Flores Aimee,
Ong Jessica,
Lowry William E.
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12978
Subject(s) - hmga2 , epithelial–mesenchymal transition , cancer research , biology , tumor progression , cancer , pathology , cell , metastasis , gene , medicine , microrna , genetics
Hmga2 functions as a chromatin‐associated factor during development, but is not expressed in most adult tissues. Expression of Hmga2 in adult tissues has been associated with a variety of human cancers. Numerous studies have implicated Hmga2 in epithelial‐to‐mesenchymal transition ( EMT ) and cancer progression through gain of function studies, but it is unclear whether Hgma2 is necessary for EMT , tumor formation or tumor progression. We deleted Hmga2 in two mouse models of squamous cell carcinoma and found this gene to be dispensable. In fact, EMT , tumor initiation and progression all appeared to be mostly unaffected by the absence of Hmga2. Tumors lacking the ability to induce Hmga2 proceeded to initiate cutaneous spindle cell and squamous cell carcinomas with all the typical pathological and molecular hallmarks of these cancers.