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Infrared A radiation promotes survival of human melanocytes carrying ultraviolet radiation‐induced DNA damage
Author(s) -
Kimeswenger Susanne,
Schwarz Agatha,
Födinger Dagmar,
Müller Susanne,
Pehamberger Hubert,
Schwarz Thomas,
Jantschitsch Christian
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12968
Subject(s) - ultraviolet radiation , infrared , dna damage , radiation , dna , ultraviolet a , ultraviolet , radiation damage , chemistry , cancer research , microbiology and biotechnology , biology , medicine , dermatology , materials science , optoelectronics , optics , genetics , physics , radiochemistry
The link between solar radiation and melanoma is still elusive. Although infrared radiation (IR) accounts for over 50% of terrestrial solar energy, its influence on human skin is not well explored. There is increasing evidence that IR influences the expression patterns of several molecules independently of heat. A previous in vivo study revealed that pretreatment with IR might promote the development of UVR‐induced non‐epithelial skin cancer and possibly of melanoma in mice. To expand on this, the aim of the present study was to evaluate the impact of IR on UVR‐induced apoptosis and DNA repair in normal human epidermal melanocytes. The balance between these two effects is a key factor of malignant transformation. Human melanocytes were exposed to physiologic doses of IR and UVR. Compared to cells irradiated with UVR only, simultaneous exposure to IR significantly reduced the apoptotic rate. However, IR did not influence the repair of UVR‐induced DNA damage. IR partly reversed the pro‐apoptotic effects of UVR via modification of the expression and activity of proteins mainly of the extrinsic apoptotic pathway. In conclusion, IR enhances the survival of melanocytes carrying UVR‐induced DNA damage and thereby might contribute to melanomagenesis.