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Biological processes in solar lentigo: insights brought by experimental models
Author(s) -
Goorochurn Ranesha,
Viennet Cécline,
Granger Corinne,
Fanian Ferial,
VarinBlank Nadine,
Roy Christine Le,
Humbert Philippe
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12937
Subject(s) - lentigo , dermatology , lesion , sun exposure , medicine , pigmentation disorder , identification (biology) , pathology , biology , melanoma , cancer research , botany
Common in ageing patient, the solar lentigo is a macular hyperpigmented skin lesion that results from chronic exposure to ultraviolet irradiations. Despite sharing numerous features with other pigmented spots, the diagnostic of this benign lesion is well characterized at the tissue level. Recent studies shed lights on several factors and their pathogenic mechanisms involved in the development of the solar lentigo. This review summarizes how diverse experimental approaches allowed the identification of several biomarkers, which contribute to a better understanding on the initiation and the maintenance of this pigmentary disorder.