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Antimicrobial peptides and wound healing: biological and therapeutic considerations
Author(s) -
Mangoni Maria Luisa,
McDermott Alison M.,
Zasloff Michael
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12929
Subject(s) - wound healing , antimicrobial peptides , antimicrobial , immune system , multicellular organism , skin repair , endogeny , immunology , biology , medicine , microbiology and biotechnology , cell , genetics , endocrinology
Repair of tissue wounds is a fundamental process to re‐establish tissue integrity and regular function. Importantly, infection is a major factor that hinders wound healing. Multicellular organisms have evolved an arsenal of host‐defense molecules, including antimicrobial peptides ( AMP s), aimed at controlling microbial proliferation and at modulating the host's immune response to a variety of biological or physical insults. In this brief review, we provide the evidence for a role of AMP s as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non‐life‐threatening skin and other epithelial injuries.