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Normal mast cell numbers in the tissues of AhR‐deficient mice
Author(s) -
Pilz Caroline,
Feyerabend Thorsten,
Sonner Jana,
Redaelli Chiara,
Peter Katharina,
Kunze Anja,
Haas Katharina,
Esser Charlotte,
Schäkel Knut,
Wick Wolfgang,
Rodewald HansReimer,
Lanz Tobias V.,
Platten Michael
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12864
Subject(s) - aryl hydrocarbon receptor , immune system , mast cell , transcription factor , microbiology and biotechnology , biology , immunology , phenotype , cell , receptor , genetics , gene
Abstract The transcription factor aryl hydrocarbon receptor (AhR) acts as an immunomodulatory molecule in several immune cell lineages. Recently, it has been implicated in development and maintenance of immune cells in barrier tissues such as skin and mucosa. To investigate its role on mast cell development and maintenance in skin, peritoneal exudate cells ( PEC s) and lymph nodes, we studied in depth their phenotype in AhR‐deficient mice. Our findings do not provide any evidence for a suspected role of the AhR in mast cell homeostasis.