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The mineralocorticoid receptor plays a transient role in mouse skin development
Author(s) -
Boix Julia,
Carceller Elena,
Sevilla Lisa M.,
MarcosGarcés Víctor,
Pérez Paloma
Publication year - 2016
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12822
Subject(s) - mineralocorticoid receptor , nuclear receptor , glucocorticoid receptor , hair follicle , receptor , mineralocorticoid , endocrinology , medicine , hormone response element , hormone , biology , transcription factor , homeostasis , glucocorticoid , aldosterone , human skin , microbiology and biotechnology , gene , biochemistry , genetics , estrogen receptor , cancer , breast cancer
3 páginas, 2 figuras. Contiene material suplemenarioGlucocorticoid (GC) hormones can bind two structurally and functionally related steroid receptors: the GC Receptor (GR or Nr3c1) and the mineralocorticoid receptor (MR or Nr3c2), which recognize the same DNA response elements and act as ligand-dependent transcription factors. While the crucial role of GR for skin homeostasis has been widely characterized, the exact role of MR in this tissue deserves further study. We assessed NR3C2 expression in developing and adult WT mouse skin and found a transient peak at embryonic day (E)16.5, which along with low levels of HSD11B2, the enzyme inactivating GCs, supports a role for GC-MR complexes in epidermal maturation. Consistent with this observation, MR-/- embryonic skin showed alterations in early epidermal differentiation that resolved postnatally. The lack of a more severe skin phenotype of MR-/- mice suggests functional compensation by GR in this tissue in the perinatal period.This work was supported by JSPS KAKENHI grant numbers 25870545 and 15K09772.\udSpanish Ministerio de Ciencia e Innovación. Grant Numbers: SAF2011-28115, SAF2014-59474-RPeer Reviewe