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Micro RNA s (mi RNA s) in the control of HF development and cycling: the next frontiers in hair research
Author(s) -
Andl Thomas,
Botchkareva Natalia V.
Publication year - 2015
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12785
Subject(s) - hair follicle , rna , microbiology and biotechnology , biology , gene expression , epigenetics , gene , genetics
Hair follicle development and its postnatal regeneration are characterized by dramatic changes in its microanatomy and cellular activity, which are controlled by multiple signalling pathways, transcription factors and epigenetic regulators, including micro RNA s (mi RNA s). mi RNA s and their targets form remarkably diverse regulatory networks, playing a key role in the execution of gene expression programmes in the different cell lineages of the hair follicle. This review summarizes the roles of mi RNA s in the control of hair follicle development, cycling and hair pigmentation, emphasizes the remaining problems/unanswered questions, and provides future directions in this rapidly growing and exciting area of research.