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Polymorphism of the E‐cadherin gene CDH 1 is associated with susceptibility to vitiligo
Author(s) -
Tarlé Roberto Gomes,
Silva de Castro Caio Cesar,
do Nascimento Liliane Machado,
Mira Marcelo Távora
Publication year - 2015
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12641
Subject(s) - vitiligo , melanocyte , pathogenesis , cdh1 , allele , biology , population , immunology , gene , genetics , cadherin , medicine , cell , melanoma , environmental health
Vitiligo is a depigmenting disorder characterized by loss of functional melanocytes from the epidermis. Experimental data suggest that defective melanocyte adhesion may underlie the pathogenesis of the disease. In particular, association between vitiligo and genetic variants of the DDR1 gene involved in melanocyte adhesion has been recently published. A subsequent, independent study revealed lower expression of DDR 1 in vitiligo lesions. Here, we expand this investigation by testing for association between vitiligo and polymorphisms of CDH1 , IL1B and NOV (formerly CCN3 ), genes belonging to the DDR1 adhesion pathway, in two population samples of distinct design. Our results reveal that alleles of marker rs10431924 of the CDH1 gene are associated with vitiligo, especially in the presence of autoimmune comorbidities.