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The NET , the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity
Author(s) -
Stephan Alexander,
Fabri Mario
Publication year - 2015
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12599
Subject(s) - neutrophil extracellular traps , innate immune system , inflammation , immunology , trap (plumbing) , extracellular , pathogen , biology , microbiology and biotechnology , chromatin , immunity , host (biology) , immune system , ecology , genetics , dna , environmental engineering , engineering
Neutrophil extracellular traps ( NET s), large chromatin structures casted with various proteins, are externalized by neutrophils upon induction by both self‐ and non‐self‐stimuli. It has become clear that NET s are potent triggers of inflammation in autoimmune skin diseases. Moreover, the ability of NET s to trap pathogens suggests a crucial role in innate host defense. However, the outcome of the encounter between pathogens and NET s remains highly controversial. Here, we discuss recent insights into the morphology and formation of NET s, their role in skin inflammation and how NET s might contribute to host protection in skin infection.