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Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma
Author(s) -
Mouchet Nicolas,
Coquart Nolwenn,
Lebonvallet Nicolas,
Le GallIanotto Christelle,
Mogha Ariane,
Fautrel Alain,
Boulais Nicholas,
Dréno Brigitte,
Martin Ludovic,
Hu Weiguo,
Galibert MarieDominique,
Misery Laurent
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12546
Subject(s) - merkel cell carcinoma , merkel cell , biology , carcinoma , cancer research , pathology , medicine
Merkel cell carcinoma is believed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly understood events. Transcriptional profiling using cDNA microarrays was performed on cells from MCPy‐negative and MCPy‐positive Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and some downregulated genes. The extensive list of genes that were identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy.