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Hair type‐specific function of canonical Wnt activity in adult mouse skin
Author(s) -
Niemann Catherin,
Schneider Marlon R.
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12509
Subject(s) - wnt signaling pathway , hair follicle , microbiology and biotechnology , morphogenesis , dermal papillae , regulator , biology , endocrinology , function (biology) , medicine , anatomy , chemistry , gene , genetics , signal transduction
Wnt/β‐catenin signalling is a key regulator of hair follicle ( HF ) morphogenesis and life‐long HF regeneration. In a recently published issue of Experimental Dermatology , Lei et al. report that sustained WNT 10B supply and pathway activation in regenerating mouse HF increased the width of hair bulbs, hair shafts and the dermal papilla (DP), and enlarged the CD 34 + HF bulge cell compartment. Notably, WNT 10B affected primarily zigzag HF s, while size and morphology of other HF types remained largely unaffected. Thus, these findings raise a number of questions regarding a HF type‐specific function of Wnt/β‐catenin and on the role of the WNT ‐stimulated DP in this process.