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Novel nanosome delivery system combined with si RNA targeting the antimicrobial gene DFB 4: a new approach for psoriasis management?
Author(s) -
Keren Aviad,
David Michael,
Gilhar Amos
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12397
Subject(s) - psoriasis , antimicrobial peptides , human skin , gene silencing , epidermis (zoology) , immune system , medicine , antimicrobial , immunology , gene , biology , microbiology and biotechnology , genetics , anatomy
In a recently published issue of the journal, Bracke et al. demonstrate an impressive improvement in psoriasiform features in allogeneic human skin grafts transplanted onto immune‐deficient mice. This improvement was achieved using a novel nanosome (SECosome) as a vehicle for delivering topically applied siRNA to human epidermis. Targeting the gene DFB4 with this delivery system, they prevented translation of the antimicrobial peptide, human β defensin‐2( hBD 2), thus normalizing the psoriasiform epidermal phenotype of siRNA/SECosome‐treated human skin grafts. This study encourages the exploration of topical gene silencing strategies in dermatology and refocuses our attention on both, the role of hBD 2 in psoriasis pathogenesis and the thorny question which animal model reflects human psoriasis most faithfully.