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What determines human body odour?
Author(s) -
Hamada Kaoru,
Haruyama Sanehito,
Yamaguchi Takashi,
Yamamoto Kayo,
Hiromasa Kana,
Yoshioka Manabu,
Nishio Daisuke,
Nakamura Motonobu
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12380
Subject(s) - snp , single nucleotide polymorphism , gene , glutathione s transferase , transporter , chemistry , genetics , biochemistry , biology , glutathione , genotype , enzyme
Human body odour and earwax type are genetically dependent on a single‐nucleotide polymorphism ( SNP ) located in the ABCC 11 gene. So far, it still remains to be clear how SNP in the ABCC 11 gene is associated with human malodour. In a recent issue of Experimental Dermatology, Baumann et al. propose one of the underlying molecular pathways. Although one of the amino acid conjugated of the odorants, Cys‐Gly‐3‐methyl‐3‐sulfanylhexanol (3M3 SH ), was not taken up by the transporter ABCC 11, glutathione conjugate of 3 MSH ( SG ‐3 MSH ) was transported by ABCC 11. Moreover, SG ‐3 MSH was processed to 3M3 SH by γ ‐glutamyl‐transferase 1 ( GGT 1), which was abundantly expressed in apocrine sweat glands. These findings may pave a way for the pharmacogenetics of human body odour and the development of innovative deodorant products.