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Treg‐enriched CD 4+ T cells attenuate collagen synthesis in keloid fibroblasts
Author(s) -
Murao Naoki,
Seino Kenichiro,
Hayashi Toshihiko,
Ikeda Masaki,
Funayama Emi,
Furukawa Hiroshi,
Yamamoto Yuhei,
Oyama Akihiko
Publication year - 2014
Publication title -
experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.108
H-Index - 96
eISSN - 1600-0625
pISSN - 0906-6705
DOI - 10.1111/exd.12368
Subject(s) - keloid , pathogenesis , immune system , immunology , fibrosis , immunohistochemistry , effector , cancer research , medicine , chemistry , pathology
Keloid is an inflammatory and fibrotic disease with an unknown pathogenesis. Regulatory T cells (Tregs) of CD 4+ lineage can suppress other effector CD 4+ T cells and modulate the immune response. A relative decrease in the number of Tregs may be involved in the pathogenesis of inflammatory and fibrotic diseases. We therefore investigated the number of Tregs in keloids using immunohistochemistry and examined the interaction between Tregs and keloid fibroblasts (KFs) using a coculture system. It was found that the ratio of Tregs/ CD 4+ T cells was lower compared with that in other common inflammatory skin conditions. In addition, Treg‐enriched CD 4+ T cells reduced collagen synthesis by KFs. Our findings suggest that a local imbalance of Tregs contributes to the development of keloids and that correction of this imbalance might represent a novel therapeutic approach to keloid fibrosis.